Donna Persico was born and raised in Cleveland Ohio. She began her acting career in Northern California, where she performed on stage, and appeared in numerous commercials. She also studied at the Playhouse West in LA. While there she performed on stage, and in film and television, including 3 seasons as a trauma nurse on NBC's hit drama ER. Her National commercials most notably include: Chase Bank, Under Armour, Proctor and Gamble, Walmart, Dr. Pepper, Chef Boyardee, Stop Smoking Campaign, Aids Awaren